Fludarabine and cytosine-arabinoside for poor-risk acute myeloid leukemia.
نویسندگان
چکیده
Thirteen relapsed or refractory AML patients were treated with the FLA regimen. A complete remission was observed in 54% of cases but the median duration of remission was short (4 months). These results suggest that the FLA regimen is not able to induce a durable complete remission in the poor-risk AML patients.
منابع مشابه
A Long Survival of a Secondary Acute Myeloid Leukemia Patient under Low-dose Cytosine Arabinoside and Valproic Acid
The prognosis of elderly patients with acute myeloid leukemia is poor, especially when they have associated diseases that affect their performance status. Azacitidine, decitabine, and low-dose cytosine arabinoside are drugs of choice for the treatment of unfit patients with acute myeloid leukemia. Their combination with other adjuvant drugs worth to be studied, in order to increase the therapeu...
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In 14 patients with acute myeloid leukemia (AML) the plasma concentration of cytosine arabinoside (Ara-C) was determined at the start of the first course of treatment at various intervals after a bolus injection. In 10 patients plasma concentration/time data were fitted to a biexponential equation and pharmacokinetic parameters were estimated from the coefficient and exponents of such equations...
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INTRODUCTION Modern therapy makes it possible for 60-80% patients with acute myeloid leukemia to achieve complete remission after induction therapy. However, most of them will relapse within six months to a year without additional cytostatic therapy. The questions regarding post-remission therapy remain unanswered. The objective of this study was to compare the survival and relapse rate among t...
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متن کاملDifferential protection of normal and malignant human myeloid progenitors (CFU-GM) from Ara-C toxicity using cycloheximide.
Cycloheximide, a reversible protein synthesis inhibitor, is thought to block DNA replication in normal cells by preventing synthesis of a labile protein. In animal systems, cycloheximide protects normal cells from cytotoxic S-phase specific agents, such as cytosine arabinoside (Ara-C). Malignant cells appear not to be susceptible to cycloheximide-induced cycle arrest and, subsequently, may not ...
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ورودعنوان ژورنال:
- Haematologica
دوره 83 3 شماره
صفحات -
تاریخ انتشار 1998